GSK-3β as a driving force in ovarian cancer
نویسندگان
چکیده
منابع مشابه
Gsk-3β
Despite continuous advances in the knowledge of breast cancer pathophysiology, this type of neoplasia remains a leading cause of cancer-related death in women, with more than 450 000 deaths every year worldwide. 1 surgery, coupled with radiation and/or che-motherapy, remains the main approach for breast cancer treatment. However, another common therapeutic option is based on the use of the estr...
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In Alzheimer's disease (AD), tau hyperphosphorylation and neurofibrillary tangle (NFT) formation are strongly associated with dementia, a characteristic and early feature of this disease. Glycogen synthase kinase 3β (GSK-3β) is a pivotal kinase in both the normal and pathological phosphorylation of tau. In the diseased state, hyperphosphorylated tau is deposited in NFTs, the formation of which,...
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Glycogen Synthase Kinase 3 (GSK-3) is a key player in development, physiology and disease. Because of this, GSK-3 inhibitors are increasingly being explored for a variety of applications. In addition most analyses focus on GSK-3β and overlook the closely related protein GSK-3α. Here, we describe novel GSK-3α and GSK-3β mouse alleles that allow us to visualise expression of their respective mRNA...
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Although glycogen synthase kinase-3 beta (GSK-3β) was originally named for its ability to phosphorylate glycogen synthase and regulate glucose metabolism, this multifunctional kinase is presently known to be a key regulator of a wide range of cellular functions. GSK-3β is involved in modulating a variety of functions including cell signaling, growth metabolism, and various transcription factors...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2006
ISSN: 1001-0602,1748-7838
DOI: 10.1038/sj.cr.7310082